CASPASE-8 INHIBITOR II
- Product Name
- CASPASE-8 INHIBITOR II
- CAS No.
- 210344-98-2
- Chemical Name
- CASPASE-8 INHIBITOR II
- Synonyms
- Z-IETD-FMK;Z-IETD-FMK?, >98%;Z-IE(OME)TD(OME)-FMK;CASPASE-8 INHIBITOR II;GRANZYME B INHIBITOR III;Z-ILE-GLU(OME)-THR-ASP(OME)-FMK;Z-IE(OME)TD(OME)-FLUOROMETHYLKETONE;CASPASE-8 INHIBITOR;Z-IE(OME)TD(OME)-FMK;inhibit,Inhibitor,Caspase,Z IETD FMK,ZIETDFMK;Z-ILE-GLU(OME)-THR-ASP(OME)-FLUOROMETHYLKETONE
- CBNumber
- CB9280050
- Molecular Formula
- C30H43FN4O11
- Formula Weight
- 654.68
- MOL File
- Mol file
CASPASE-8 INHIBITOR II Property
- Boiling point:
- 925.7±65.0 °C(Predicted)
- Density
- 1.247±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- Soluble in DMSO
- form
- Powder
- pka
- 11.12±0.46(Predicted)
N-Bromosuccinimide Price
- Product number
- B3232
- Product name
- Z-IETD-FMK
- Packaging
- 1mg
- Price
- $240
- Updated
- 2021/12/16
- Product number
- B3232
- Product name
- Z-IETD-FMK
- Packaging
- 20ul(10mM)
- Price
- $125
- Updated
- 2021/12/16
- Product number
- B3232
- Product name
- Z-IETD-FMK
- Packaging
- 100ul(2mM)
- Price
- $125
- Updated
- 2021/12/16
- Product number
- AK316562
- Product name
- Z-IETD-FMK
- Purity
- 95+%
- Packaging
- 1mg
- Price
- $204
- Updated
- 2021/12/16
- Product number
- 32758
- Product name
- Z-Ile-Glu(OMe)-Thr-DL-Asp(OMe)-fluoromethylketone
- Packaging
- 1MG
- Price
- $287.5
- Updated
- 2021/12/16
CASPASE-8 INHIBITOR II Chemical Properties,Usage,Production
Uses
A potent, cell-permeable, and irreversible inhibitor of caspase-8 and granzyme B. Effectively inhibits influenza virus-induced apoptosis in HeLa cells. Also inhibits granzyme B.
Biological Activity
z-ietd-fmk is an inhibitor of caspase 8 [1].z-ietd-fmk inhibits t cell proliferation induced by pha or anti-cd3 plus anti-cd28 without toxicity of resting t cells. the mechanism of this inhibition of z-ietd-fmk has been proved not through the effect on il-2 secretion or ifn-γ production but the decrease of cd25 expression. experiments show that z-ietd-fmk has no effect on normal cell growth when there is no activation signal. z-ietd-fmk has also been found to significantly inhibit nf-κb activation when the concentration is 100μm [1].apart from the ability of inhibiting cell proliferation, z-ietd-fmk is reported to inhibit trail-mediated killing in cells. it protects the procaspases 9, 2, and 3, and protects parp to a similar extent in both hct116 and sw480 cells [2].
target
caspase 8
References
[1] c.p. lawrence, s.c. chow. suppression of human t cell proliferation by the caspase inhibitors, z-vad-fmk and z-ietd-fmk is independent of their caspase inhibition properties. toxicology and applied pharmacology. 2012, 265: 103-112.
[2] nesrin özören, kunhong kim, timothy f. burns, et al. the caspase 9 inhibitor z-lehd-fmk protects human liver cells while permitting death of cancer cells exposed to tumor necrosis factor-related apoptosis-inducing ligand. cancer research. 2000, 60: 6259-6265.
CASPASE-8 INHIBITOR II Preparation Products And Raw materials
Raw materials
Preparation Products
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